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Oteoporosis and HRT
Risk of fragility fracture is decreased while taking HRT and that this benefit (1):
Table: Absolute rates of any fragility fracture for HRT compared with no HRT (or placebo), different durations of HRT use and time since stopping HRT for menopausal women
Current HRT users | Treatment duration <5 years | Treatment duration 5-10 years | >5 years since stopping treatment | ||
Women on any HRT | RCT estimate | 23 fewer (-10 to -33) | 25 fewer (-9 to -37) | No available data | No available data |
Women on any HRT | Observational estimate | 16 fewer (-15 to -18) | 15 fewer (-11 to -17) | 18 fewer (-15 to -20) | 2 more (-19 to 27) |
A Cochrane review which included data from 19 trials (n=42,830) investigated the long-term effect of HRT on multiple outcomes, including the incidence of hip fractures, clinically diagnosed vertebral fractures and total clinically diagnosed fractures. The majority of the evidence was derived from two large RCTs conducted by the WHI. The fracture-related data were considered as outcomes of secondary harm, therefore no power calculations were provided (2).
SIGN suggest:
Reference:
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