Last reviewed dd mmm yyyy. Last edited dd mmm yyyy
Note that there has been a voluntary worldwide withdrawal of the 'COX-2 selective NSAID' rofecoxib (Vioxx/VioxxAcute) by the manufacturer. This follows new clinical trial results showing an increased risk of confirmed serious thrombotic events (including myocardial infarction and stroke) compared to placebo, following long-term use (2).
There has been advice for Prescribers in light of concerns about cardiovascular safety of COX-2 inhibitors (3)
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