included in the pooled clinical trial database of 3,082 patients treated with venlafaxine were 14 patients who had taken an overdose of venlafaxine - all 14 patients survived the overdose and recovered without sequelae. One patient ingested 2.75 grams of venlafaxine and did suffer two epileptiform convulsions and developed a prolonged QT interval
monoamine oxidase inhibitors are contraindicated with venlafaxine - it is advised that there is a 14-day washout period between stopping an MAOI and starting venlafaxine treatment. The 'Serotonin syndrome' may occur as a result of inadvertent consumption of venlafaxine and an MAOI
during clinical trials, discontinuation phenomena from venlafaxine were reported with abrupt discontinuation after daily doses of 150 mg per day or higher - these usually occurred within 2 days of significant dose reduction and generally resolved within 7 days of stopping treatment. The commonly reported phenomena were headache, nausea and dizziness (1)
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