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Switching antidepressant (mirtazapine to vortioxetine) in adults

Authoring team

Mirtazapine to vortioxetine

  • limited experience with this switch so extra caution is required to avoid serotonin syndrome

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

Taper, washout and switch

  • alternatively, gradually reduce the dose of mirtazapine and stop; wait for a period before starting vortioxetine. Clinicians should decide the duration of the washout period on a case-by-case basis.

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