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Switching antidepressant (SSRIs to trazodone) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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SSRIs to trazodone

Cross-taper

  • cross-tapering can generaly be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

Additional caution when switching from fluoxetine or paroxetine

  • fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping, as fluoxetine and its active metabolite have a long half-life
  • if switching from fluoxetine or paroxetine, caution is required as they are potent inhibitors of the liver enzyme CYP2D6 which is involved in the metabolism of trazodone. There is therefore there is a risk of raised trazodone levels in the body when they are administered together.

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