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Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The aetiology of this condition is unknown.

Goodpasture's syndrome often starts after an upper respiratory tract infection (there is an association with influenza A2 virus)

  • during the 1919 influenza epidemic, Goodpasture described a disease association between pulmonary hemorrhage and rapidly progressive glomerulonephritis (RPGN)
    • in 1977, Lerner et al. discovered that the sera and/or kidneys of some patients with this syndrome contained antibodies against the glomerular basement membrane

There is a strong association with HLA-DR2 (about 90%). A more severe form of the disease occurs in patients who also have HLA-B7.

Reference:

  1. E. Goodpasture. The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 1919; 158:863–870

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