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Nephrocalcinosis

Authoring team

Nephrocalcinosis is parenchymal calcium deposition in the kidney. It is usually a consequence of hypercalcaemia, and there may be intracellular renal damage caused by calcium overload.

Initial deposits occur in the mitochondria of renal cells, later whole nephrons become calcified. The result is patchy atrophy and calcification of the kidney.

Causes include:

  • malignancy (commonest cause)
  • multiple myeloma
  • hyperparathyroidism
  • sarcoidosis
  • vitamin D intoxication

Investigations:

  • blood tests - hyercalcaemia, increased creatinine
  • urine tests - haematuria, proteinuria, pyuria, hypercalciuria
  • abdominal Xray - may reveal renal calculi or nephrocalcinosis





Treatment aims to correct the hypercalcaemia.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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