This is the most common form of lung tumour accounting for approximately 40% of cases. It is more common in males and is the lung tumour most closely associated with cigarette smoking.
Microscopic features include keratinisation and intercellular bridge formation - 'prickles'. Squamous dysplasia, metaplasia, or carcinoma in situ may be observed in the vicinity of the tumour.
Local growth is rapid.Metastasis occurs via lymphatic and haematogenous routes, but tends to be later than for other types of carcinoma.
Spindle cell squamous carcinoma is a variant which may be misdiagnosed as sarcoma. However, immunohistochemical staining and electron microscopy clearly differentiate the two.
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