the predominance of respiratory involvement, especially in GPA (Wegener's), led to investigation of the role of inhaled agents in the development of GPA
they observed no increase in inhaled particulates and fumes in GPA in general, but a significant increase in those with respiratory disease
a number of other possible trigger factors have also been reported, including silica, solvents, allergy and vaccination. A number of drugs have been implicated in the development of ANCA associated vasculitis (AAV)
patients with high-titre MPO antibodies are more likely to have taken hydralazine, propylthiouracil or allopurinol
leucotriene antagonists have been associated with development of EGPA (Churg Strauss), probably by unmasking pre-existing disease
Reference:
Mahr A et al. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): evolutions in classification, etiopathogenesis, assessment and management. Curr Opin Rheumatol. 2014 Jan;26(1):16-23.
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