cyclophosphamide - administered either by continuous oral treatment or intermittent pulse therapy once a month iv
maintenance therapy can use a lower dose or more widely spaced iv pulse (6-12 weeks)
reserved for the treatment of life-threatening disease, especially lupus nephritis, vasculitis and cerebral disease
studies undertaken at the National Institutes of Health (NIH) revealed improved renal survival in those treatment regimens that included cyclophosphamide in addition to prednisolone
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