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Cyclophosphamide in SLE

Authoring team

  • cyclophosphamide - administered either by continuous oral treatment or intermittent pulse therapy once a month iv

  • maintenance therapy can use a lower dose or more widely spaced iv pulse (6-12 weeks)

  • reserved for the treatment of life-threatening disease, especially lupus nephritis, vasculitis and cerebral disease

  • studies undertaken at the National Institutes of Health (NIH) revealed improved renal survival in those treatment regimens that included cyclophosphamide in addition to prednisolone

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