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Pathogenesis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

There are probably multiple factors involved in the pathogenesis of fibromyalgia syndrome. However the sleep disturbance is thought to be of major importance:

  • there is a loss of non-REM sleep
  • a fibromyalgia-like syndrome may be induced in normal volunteers be depriving them of non-REM sleep

Reduced aerobic fitness may also be important.

Affective symptoms are associated with the fibromyalgia syndrome but whether they are primary or secondary is unknown.

A viral cause for the fibromyalgia syndrome is not supported by any evidence.

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