Lupus anticoagulants (LA) are a heterogeneous class of immunoglobulins which has a paradoxical effect on coagulation: in vivo they are associated with recurrent thrombosis and in vitro they increase the phospholipid dependant clotting time (known as lupus anticoagulant activity) (1)
The LA anti-phospholipid often occurs in association with anti-cardiolipin antibodies (aCL) - 59% of patients with SLE having LA also have aCL, and 45% with SLE and aCL, also have LA.
Clinically theses antibodies are important:
Reference:
Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page