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Aetiology

Authoring team

The cause of most cases of PAN is unknown. It has been suggested that deposition of immune complexes in the arterial wall initiates an inflammatory process. Some conditions are linked with PAN and offer possible aetiological information: (1)

PAN may occur following the administration of drugs which are antigenic or act as haptens:

  • sulphonamides
  • gold compounds
  • penicillins

  • acute infections may precipitate PAN:
    • hepatitis B: HBsAg is detected in 20-40% of patients with PAN
    • staphylococcal infections

  • PAN is a rare complication of serum sickness

  • PAN is associated with lymphoproliferative disorders:
    • myeloma
    • lymphoma
    • hairy cell leukaemia

1. Polyarteritis Nodosa - a contemporary overview. U.S. National Library of Medicine 2016. Available from: https://pubmed.ncbi.nlm.nih.gov/26884100/

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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