Klinefelter’s syndrome (KS) was first described by Harry Klinefelter in 1942 as an endocrine disorder of unknown etiology. In 1959, Jacobs et al recognized KS as a chromosomal disorder in which the patients had an extra X chromosome to a normal male karyotype, 46 XY (1).
This is the most common cause of male hypogonadism. Majority of patients are undiagnosed due to non specific clinical findings while in some cases, diagnosis is made post mortem (4).
Increased maternal age is linked with an increased risk of having a child with KS (2). Affected individuals have a normal life span.
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