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Tolbutamide and alcohol

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Tolbutamide clearance from the bloodstream is increased if a patient drinks heavily. Levels of tolbutamide are approximately halved in those drinking 30 units per day.

Reference:

  • Drugs and Therapeutics Bulletin (1996), Drugs and alcohol: harmful cocktails?, 34 (5), 36-8.
  • Iber FL (1977), Drug metabolism in heavy consumers of ethyl alcohol, Clin Pharmacol Ther, 22, 735-42.

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