ISIS-4 examined the role of the following interventions in the management of acute myocardial infarction:
Using captopril, there was a significant reduction in 5 week mortality versus placebo which appeared to be maintained in the long-term. There was an increase of:
Using mononitrate, there was no significant reduction in 5 week mortality. There was an increase of 15 per 1000 in hypotension.
Using magnesium, there was no significant reduction in 5 week mortality.
Conclusions:
Reference:
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