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Drug interactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Cyclosporin interacts with several drugs, some causing increased levels of cyclosporin, others, reduced levels.

Drugs that increase the levels of cyclosporin in the blood include:

  • ketoconazole and other anti-fungals
  • some calcium channel blockers e.g. diltiazem and verapamil
  • oral contraceptives
  • erythromycin

Drugs than induce liver enzymes, reduce the levels of cyclosporin in the blood include:

  • barbiturates
  • phenytoin
  • carbamazepine
  • rifampicin

Increased blood levels of cyclosporin may result in toxic side-effects while reduced levels increase the risk of rejection or treatment failure.

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