This is an immunosuppressive drug that is becoming the drug of choice for transplantation. It may be of use in the management of severe autoimmune diseases.
Cyclosporin blocks cytotoxic T cell activation by:
The bioavailability of cyclosporin A is dependent on the presence of bile salts which may be reduced in patients with liver transplantation. This problem however has been significantly reduced since the advent of a micro-emulsion formulation of cyclosporin whose absorption is independent of bile in the small intestine.
Patients treated with cyclosporin A should have their blood pressure and renal function monitored regularly.
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