Raynaud's phenomenon is characterised by episodic attacks of digital vasospasm and ischaemia on exposure to cold, or less commonly, emotional stress. This results in a characteristic triphasic colour change in extremities (usually in fingers or toes)
Ear and nose involvement can be seen as well in some patients (1). Attacks vary from minutes to hours. There may be associated hyperhidrosis.
The disease may occur as
A systematic review was undertaken regarding vasodilators in the management of Raynaud's phenomenon. The systematic review considered calcium channel blockers as the drug of choice in this condition and therefore considered alternative vasodilator agents to calcium channel blockers in the management of this condition (3). The systematic review considered:
This updated review (15 studies [7 new]; n=635) found the evidence is insufficient to support use of vasodilators (other than calcium channel blockers); they may even worsen disease (3)
Reference:
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