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Associated diseases

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

84% of patients with primary biliary cirrhosis have at least one other autoimmune disease.

These include:

  • autoimmune thyroiditis
  • Sjogren's syndrome
  • CREST syndrome
  • scleroderma
  • rheumatoid arthritis
  • fibrosing alveolitis

Rarer associations include:

  • jejunal villous atrophy
  • bullous pemphigoid
  • capillaritis
  • lichen planus
  • IgM-associaed membranous glomerulonephritis
  • renal tubular acidosis
  • dermatomyositis
  • polymyositis
  • mixed connective tissue disease
  • systemic lupus erythematosus
  • Grave's disease
  • ulcerative colitis
  • autoimmune thrombocytopaenia
  • breast cancer - there is a four fold increase in incidence in women with PBC

Note:

  • natural history or clinical presentation of PBC is not modified by autoimmune comorbidities (1)

Reference:

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