The risk of complications with the combined pill increase steeply in smokers over the age of 35 years so that other methods of contraception are recommended. In patients aged 35 - 44 years, the mortality rates are:
Users of low oestrogen pills have a higher relative risk of myocardial infarction and haemorrhagic stroke - due to the higher level of progesterone - but a reduced risk of cerebral thrombosis.
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