Combined oral contraceptives and breast cancer risk

Women should be advised that current use of CHC (combined hormonal contraception) is associated with a small increased risk of breast cancer which reduces with time after stopping CHC (1).

A study (n=9498 incident invasive breast cancer [BC]; 18,171 matched controls) found current or recent hormonal contraceptive use linked to similarly increased BC risk, regardless of whether oral combined, POP, or injectable/implant/intrauterine device of progestogen was last used (2):

• a relative increase of approximately 20% to 30% in breast cancer risk associated with current or recent use of either combined oral or progestagen-only contraceptives
• when the authors combined the findings with results from previous studies, which included women in a wider age range
  • 15-year absolute excess risk of breast cancer associated with use of oral contraceptives ranged from 8 per 100,000 users (increase in incidence from 0.084% to 0.093%) for use from age 16 to 20 to about 265 per 100,000 users (from 2.0% to 2.2%) for use from age 35 to 39

Reference:

1. FSRH (July 2019). Combined Hormonal Contraception.
2. Fitzpatrick D et al. Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case.control study and meta-analysis. PLOS Medicine March 21st 2023.