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Tranexamic acid

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Tranexamin acid is used in situations where excessive haemorrhage cannot be controlled e.g.:

  • post-operatively e.g prostatectomy, bladder surgery
  • menorrhagia associated with IUCD's
  • haemophiliac dental extraction
  • epistaxis
  • reduce the effect of fibrinolytic drugs
  • as a second-line agent in hereditary haemorrhagic telangiectasia

It competitively inhibits the conversion of plasminogen to plasmin.

Cautions / contra-indications:

  • massive haematuria from upper renal tract as may cause ureteric thrombotic obstruction
  • history of thromboembolic disease
  • pregnancy

It interacts with the oral contraceptive pill to increase the risk of thrombosis.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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